| THO 100 Top 100 Artists of 2000 Compiled from the weekly Top Hits Online charts of 2000 |
| 1 | 'N Sync | Chart History |
| 2 | Britney Spears | Chart History |
| 3 | Christina Aguilera | Chart History |
| 4 | Vanessa Chinitor | Chart History |
| 5 | Madonna | Chart History |
| 6 | Backstreet Boys | Chart History |
| 7 | Destiny's Child | Chart History |
| 8 | Faith Hill | Chart History |
| 9 | Enrique Iglesias | Chart History |
| 10 | Matchbox Twenty | Chart History |
| 11 | Eminem | Chart History |
| 12 | Vertical Horizon | Chart History |
| 13 | Savage Garden | Chart History |
| 14 | Whitney Houston | Chart History |
| 15 | 3 Doors Down | Chart History |
| 16 | Santana | Chart History |
| 17 | LeAnn Rimes | Chart History |
| 18 | Robbie Williams | Chart History |
| 19 | Celine Dion | Chart History |
| 20 | Kim Wilde | Chart History |
| 21 | Pink | Chart History |
| 22 | Toni Braxton | Chart History |
| 23 | Ricky Martin | Chart History |
| 24 | Lonestar | Chart History |
| 25 | Red Hot Chili Peppers | Chart History |
| 26 | Creed | Chart History |
| 27 | Jessica Simpson | Chart History |
| 28 | Blink-182 | Chart History |
| 29 | Mariah Carey | Chart History |
| 30 | Third Eye Blind | Chart History |
| 31 | Sonique | Chart History |
| 32 | Everclear | Chart History |
| 33 | Melanie C | Chart History |
| 34 | Sisqo | Chart History |
| 35 | Janet Jackson | Chart History |
| 36 | Aaliyah | Chart History |
| 37 | Jennifer Lopez | Chart History |
| 38 | Dixie Chicks | Chart History |
| 39 | Indochine | Chart History |
| 40 | U2 | Chart History |
| 41 | Moby | Chart History |
| 42 | 98 Degrees | Chart History |
| 43 | David Hallyday | Chart History |
| 44 | Papa Roach | Chart History |
| 45 | Macy Gray | Chart History |
| 46 | Nine Days | Chart History |
| 47 | The Product G&B | Chart History |
| 48 | Martina McBride | Chart History |
| 49 | Bon Jovi | Chart History |
| 50 | Eiffel 65 | Chart History |
| 51 | Sting | Chart History |
| 52 | The Corrs | Chart History |
| 53 | Limp Bizkit | Chart History |
| 54 | No Doubt | Chart History |
| 55 | BBMak | Chart History |
| 56 | Marc Anthony | Chart History |
| 57 | Filter | Chart History |
| 58 | Westlife | Chart History |
| 59 | Dido | Chart History |
| 60 | Reba McEntire | Chart History |
| 61 | Kylie Minogue | Chart History |
| 62 | All Saints | Chart History |
| 63 | Bloodhound Gang | Chart History |
| 64 | Lara Fabian | Chart History |
| 65 | Alice Deejay | Chart History |
| 66 | Shedaisy | Chart History |
| 67 | Mandy Moore | Chart History |
| 68 | George Strait | Chart History |
| 69 | Nelly | Chart History |
| 70 | Travis | Chart History |
| 71 | Florent Pagny | Chart History |
| 72 | Rob Thomas | Chart History |
| 73 | Samantha Mumba | Chart History |
| 74 | Ronan Keating | Chart History |
| 75 | Barenaked Ladies | Chart History |
| 76 | Jo Dee Messina | Chart History |
| 77 | Debelah Morgan | Chart History |
| 78 | Lee Ann Womack | Chart History |
| 79 | Tim McGraw | Chart History |
| 80 | Nina Gordon | Chart History |
| 81 | Green Day | Chart History |
| 82 | Brian McKnight | Chart History |
| 83 | Mya | Chart History |
| 84 | Tom Jones | Chart History |
| tie | Mousse T | Chart History |
| 86 | Foo Fighters | Chart History |
| 87 | A-Ha | Chart History |
| 88 | Dandy Warhols | Chart History |
| 89 | Volumia | Chart History |
| 90 | Amber | Chart History |
| 91 | Dr. Dre | Chart History |
| 92 | Modjo | Chart History |
| 93 | Joe | Chart History |
| 94 | Alan Jackson | Chart History |
| 95 | Steps | Chart History |
| 96 | Stone Temple Pilots | Chart History |
| 97 | Souldecision | Chart History |
| tie | Thrust | Chart History |
| 99 | Spice Girls | Chart History |
| 100 | Boyzone | Chart History |
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